About Haematex



Haematex Research Pty Ltd was formed in Sydney in 2004 by scientists from Australian hospital laboratories and Gradipore/Life Diagnostics. Gradipore had international success in commercializing the dilute Russells viper venom (RVV) test for lupus anticoagulants and we have developed this further to a liquid stable and more specific system.

Our projects have included developing a factor Xa activated clotting test (XACT) for procoagulant phospholipid (PPL test) licenced to Diagnostica Stago. This detects prothrombotic risk in cancer and (probably) cardiac disease.

We have also assisted Hyphen BioMed, Sysmex, Enzyme Research Lab and others in successful R&D projects. We have developed methods for collagen, ellagic acid complex and other compounds useful in coagulation testing and blood/biomaterials research.

Our special interest is in the development of improved tests for bleeding and clotting disorders. Especially for acquired and therapeutic coagulation inhibitors. Thus, we have novel APTT reagents and a RVV-based test for all the new direct oral anticoagulants (DOACs).

Most recently we have developed DOAC Stop™, an activated carbon product which specifically withdraws DOACs from patient samples, thus allowing valid routine tests to be carried out despite the initial presence of DOACs. We would be delighted to interact with any like-minded researchers.


Selected Research


Clotting tests correlate better with DOAC concentrations when expressed as a "Correction Ratio"; results before/after extraction with the DOAC Stop reagent.
Thrombosis Research. 2019; 179: 69-72.
Exner T, Favresse J, Lessire S, Douxfils J, Mullier F.


Simple method for removing DOACs from plasma samples.
Thrombosis Research. 2018; 163: 117-122.
Exner T, Michalopoulos N, Pearce J, Xavier R, Ahuja M.


An optimized dRVVT-based assay to estimate the intensity of anticoagulation in patients treated with direct oral anticoagulants.
Thrombosis Research. 2017; 157: 29-37.
Sennesael AL, Exner T, Chatelain B, Lessire S, Larock AS, Vancraeynest C, Pochet L, Dogne JM, Spinewine A, Mullier F, Douxfils J.


Testing for new oral anticoagulants with LA-resistant Russells viper venom reagents. An in vitro study
Thromb Haemost. 2013 Apr;109(4):762-5. doi: 10.1160/TH12-11-0842. Epub 2013 Jan 31.
Thomas Exner, Lisa Ellwood, Jenny Rubie, Aileen Barancewicz


Clinical evaluation of a new functional test for detection of plasma procoagulant phospholipids
Blood coagulation & fibrinolysis: an international journal in haemostasis and thrombosis. 08/2009; 20(7):494-502. DOI: 10.1097/MBC.0b013e32832c5e51
Patrick van Dreden · Aurélie Rousseau · Sylviane Fontaine · Barry J Woodhams · Thomas Exner


Increased procoagulant phospholipid activity in blood from patients with suspected acute coronary syndromes: A pilot study
Blood Coagulation and Fibrinolysis 08/2005; 16(5):375-9. DOI:10.1097/01.mbc.0000173465.45613.a3.
Thomas Exner · Joanne E Joseph · David Connor · Joyce Low · David D F Ma


A new activated factor X-based clotting method with improved specificity for procoagulant phospholipid
Blood Coagulation and Fibrinolysis 01/2004; 14(8):773-9. DOI:10.1097/01.mbc.0000061366.73802.df
Thomas Exner · Joanne Joseph · Joyce Low · David Connor · David Ma


Conceptions and Misconceptions in Testing for Lupus Anticoagulants
Journal of Autoimmunity 10/2000; 15(2):179-83. DOI:10.1006/jaut.2000.0392
Thomas Exner


Detecting APC-resistant factor V
Blood Coagulation and Fibrinolysis 10/1999; 10(6):359-66. DOI:10.1097/00001721-199909000-00006
D B Rylatt · C Hohnen-Behrens · R L Pilgrim · L E Dickeson · M Neal · T Exner ·

A monoclonal antibody against prothrombin fragment 1 behaves like a lupus anticoagulant (Letter)
Thrombosis and Haemostasis 04/1999; 81(3):470-1.
T Exner · M Kraus ·


Guidelines for Testing and Revised Criteria for Lupus Anticoagulants (SSC Subcommittee for standardization of Lupus Anticoagulants.)
Thrombosis and Haemostasis. 1991; 65; 320-322.
T Exner · Triplett DA · Taberner D · Machin SJ