Our newest product is DOAC Stop; a vital tool for any lab troubled by the new or direct oral anticoagulants. DOAC Stop removes all DOACs from sample plasmas without affecting other tests of haemostasis. Its effect is best measured using our uniformly-sensitive RVV-based DOAC-Test reagent and it complements our HEP-Stop (HRRS) for investigating unexpectedly prolonged APTT results. For lupus anticoagulant testing we have liquid stable dRVT-LS (LA Sensitive) and dRVT-LR (LA Resistant) reagents with "LS/LR" ratios being unaffected by VKA (Warfarin) or DOACs. There is also SACT II, a non-settling alternative to the classic kaolin clotting time (KCT) reagent and the Intrinsin APTT reagents; LA Sensitive and LA-Resistant. All these can be supplied ready for use or as powders for your own reconstitution. Our factor Xa- activated clotting time (XACT) test kit detects procoagulant phospholipids such as those on microparticles and activated platelets. We can supply synthetic phospholipid blends and also other procoagulant products such as soluble ellagic acid and equine collagen.

DOAC-Stop

mini-tablets

 

DOAC-Stop removes all types of Direct Oral Anti-Coagulants (DOACs; dabigatran, apixaban, rivaroxaban, and edoxaban, etc) from test plasmas with minimal effect on underlying blood clotting tests. Just add one mini-tablet per 1ml test plasma (volume is not critical), mix for 5 minutes and centrifuge down the adsorbent. The resulting plasma is then depleted of DOACs and yields similar APTT, dRVVT , PT(INR) and other results as if DOACs had not been present.

Reversing agents coming into therapeutic use for individual DOACs are not widely available for lab tests. DOAC-Stop is now offered for simplifying the diagnostic problems associated with DOACs. It absorbs up to an estimated 2,000ng/ml of any DOAC in less than 5 minutes. Unlike therapeutic additives for reversing DOACs it leaves no residual effect. It can be used for checking if DOACs are present in samples giving unexpectedly prolonged clotting test or abnormal chromogenic test results. There is negligible interference with vitamin K antagonist or heparinoid anticoagulants. Plasmas treated with DOAC-Stop can be used for valid factor assays and in testing for thrombotic risk. In particular it can prevent false LAC positive results due to DOACs or other agents in testing for lupus anticoagulants. Currently RUO. Patent pending.

Please contact Haematex Research (haematex@tpg.com.au) for more information.



Now published:
"Simple method for removing DOACs from plasma samples".
Exner T, Michalopoulos N, Pearce J, Xavier R, Ahuja M.
Thrombosis Research. 2018; 163: 117-122.



DOAC Stop is available in Europe with CE mark from


GERMANY:
Haemochrom Diagnostica GmbH
Renteilichtung 1
DE-45134 Essen
Phone: +49 (0)201 8 43 77-0
Fax: +49 (0)201 53 64 56
E-mail: info@haemochrom.de

The NETHERLANDS:
NODIA BV
Keurenplein 5
1069 CD Amsterdam
Phone: +31 (0)20 610 80 06
Fax: +31 (0)20 610 27 91
E-mail: info@nodia.nl
Ordering: ordering@nodia.n

UNITED KINGDOM:
Quadratech Diagnostics Ltd
P.O. Box 167
Epsom
Surrey, KT18 7YL
Phone: +44(0)33 3321 2371
Fax: +44(0)33 3321 2372
E-mail: info@quadratech.co.uk

USA/CANADA
Diapharma Group, Inc.
8948 Beckett Road
West Chester, OH 45069
Customer Service and Orders: 1.800.526.5224
Technical Support and Product Information: 1.800.447.3846
Local: 513.860.9324
Fax: 513.860.9635
E-mail: info@diapharma.com

CZECH REPUBLIC
Diagnostica, a. s.
Za tratí 686
196 00 Praha 9-Čakovice
Phone: +420 266 315 909
Fax: +420 266 316 000
E-mail: info@diagnostica.cz