Our newest product is DOAC Stop; a vital tool for any lab troubled by the new or direct oral anticoagulants. DOAC Stop removes all DOACs from sample plasmas without affecting other tests of haemostasis. Its effect is best measured using our uniformly-sensitive RVV-based DOAC-Test reagent and it complements our HEP-Stop (HRRS) for investigating unexpectedly prolonged APTT results. For lupus anticoagulant testing we have liquid stable dRVT-LS (LA Sensitive) and dRVT-LR (LA Resistant) reagents with "LS/LR" ratios being unaffected by VKA (Warfarin) or DOACs. There is also SACT II, a non-settling alternative to the classic kaolin clotting time (KCT) reagent and the Intrinsin APTT reagents; LA Sensitive and LA-Resistant. All these can be supplied ready for use or as powders for your own reconstitution. Our factor Xa- activated clotting time (XACT) test kit detects procoagulant phospholipids such as those on microparticles and activated platelets. We can supply synthetic phospholipid blends and also other procoagulant products such as soluble ellagic acid and equine collagen.


Heparin Resistant Recalcifying Solution


Heparins are widely used in hospitals as anticoagulants. Unfractionated heparin is usually monitored using APTT and thrombin time tests. Often plasma samples are not identified as containing heparin and it may be present as an unexpected contaminant. Thus the reason for prolonged APTT or KCT tests may not be apparent and laboratory diagnosis may not be simple. Laboratories may find it useful to have a simple method for confirming the presence of heparin before going on to other investigations as may be required. The HRRS can be substituted for the usual M/40 calcium chloride solution in APTT and KCT tests to virtually eliminate the effect of unfractionated heparin concentrations up to 1 u/ml in normal plasma.

Several methods are available to remove heparin including heparinase enzyme (expensive), adsorbing agents such as ECTEOLA cellulose (not so simple) and specially treated filters. Some polymers have also been widely used to neutralise heparin, however, in excess, they can interfere with contact activators used in most APTT reagents. Thus it is more reliable to add the heparin neutralising agent in the calcium chloride solution after the contact activation stage in APTTs or KCTs. The HRRS is a simple and unique product which we believe will play a regular role in routine coagulation testing. Since identifying this as a potential necessity for every coagulation lab, we are currently establishing new manufacturing to handle rapid growth.

Blue-coded M/40 (0.02M) calcium solution containing a heparin-neutralising agent. Reverse the effect from heparins and heparinoids in APTT, SACT and NAPTT tests.

X9107AE - 12 x 5 ml vials