Haematex Newsletter

an occasional update from Haematex with commentary on new products, research and industry developments.

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Issues -

May 2020

Haematex -
your Local Coagulation Resource

Corona Corner

Much excitement about the thrombotic complications emerging in Covid-19 disease. Heparin iv does not seem to be adequate in preventing this. An aerosol form is being used in one study. Low molecular weight heparin has been proposed in another. Roche have ramped up production of their clot-buster TPA (Activase) for emergency use. It's funny that we get more information about this pandemic from regular news outlets than from our professional journals.
A group at the Royal London Hospital (Bowles L, Platton S, Yartey N, et al New Engl J Med. DOI:10.1056) have shown a high incidence of lupus anticoagulant among patients with severe coronavirus disease. The thrombotic mechanism behind LA remains unclear and DOACs have recently been shown to not work in this type of autoimmune thrombosis. Endothelial damage, cytokine storm, effects of angiotensin converting enzyme, what is happening? Will the immunoglobulins being isolated from recovered patients also contain lupus anticoagulant? It seems that we may learn a lot from this pandemic apart from how to survive in isolation.
At Haematex we have excellent lupus anticoagulant tests available. Our ARTG-listed/TGA approved Cephen reagent pair from Hyphen BioMed are already in use in several Australian labs. Our Intrinsins, (which are similar, except made locally), have been internally validated by several other users.

  Cephen (ARTG TGA) Intrinsin (RUO)
Lupus Resistant  CK515K (5)  8 x 5ml  X9811-10  1 x 10ml 
CK515L (5)  12 x 5ml  X9811  5 x 10ml 
CK512K (2.5)  6 x 2.5ml     
Lupus Sensitive  CK522K (2.5LS)  6 x 2.5ml  X9801-10  1 x 10ml 
X9801  5 x 10ml 

HBM are close to finally releasing their dRVVT "Screen/Confirm" pair which have been in development for some time and which have had several excellent evaluations. Our own Haematex dRVVT reagents are more reliable than those affected by DOACs as shown in a paper by Barbara Depreter and Katrien M.J. Devreese "Dilute Russell's viper venom time reagents in lupus anticoagulant testing: a well-considered choice" Clin Chem Lab Med 2016. However, they are only for research use as the cost of local regulatory requirements is excessive for our humble company. (Note that there are a few errors in the Devreese paper).

We've gone dotty!

We would like to introduce a new product developed here at the Haematex laboratories called "Inhibitor Dots". These are strips of plastic with a 500ng "dot" of a DOAC or 0.3iU heparin at one end. We have available dabigatran, apixaban, rivaroxaban, edoxaban and betrixaban available. A strip can be dipped into 1ml of any fluid to release 500ng into that plasma, thus making a QC control possible from any plasma. These strips were developed mainly to allow labs to easily evaluate DOAC Stop-our DOAC neutralizing agent. We would like to thank all participants from our recent Rivaroxaban Dot survey.



For a limited time only, we are taking 20% off the regular price of #221406 BIOPHEN FVIII (2 x 6ml) kits, normally priced at $576.00, now $460! This is our popular Chromogenic assay for the measurement of Factor VIII:C activity in human citrated plasma, Factor VIII:C concentrates, or biological fluids. Automated or Manual method. This assay offers two working ranges for Factor VIII:C (Low: 0 to 25% and High: 0 to 200%).
Associated calibrator and controls are available: BIOPHEN Plasma Calibrator 222101), BIOPHEN Normal Control Plasma223201 and BIOPHEN Abnormal Control Plasma 223301.


We've got your regular stock covered!

In anticipation of supply chain disruptions from our French Hyphen product lines, we have stocked up with your popular items and can immediately dispatch DTI kits, FVIII kits, Cephen (CK515L/CK512K and CK522K) and calibrators/controls for Orgaran and dabigatran. HRRS and DOAC-Stop made locally are also stocked up and ready to dispatch.

Thanks for reading, we are grateful that we can act as your local coag news resource.