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Direct oral anticoagulants (DOACs) are available as rapidly-dissolving dry film in a vial. The inhibitors dissolve within 10 minutes into 1ml of fluids such as blood, plasma or urine, thereby transferring the compound into samples. Inhibitor ref in vials makes it easier to mix and store the sample. Plasmas treated using Inhibitor Ref may be used as positive controls in clotting, chromogenic or other assays. Dilutions can be prepared in pooled normal plasma, blood or other fluids to set up calibration curves.
Haematex has a new supported film technology adaptable to any potent, stable agent. It allows a library of compounds to be held as a flat collection rather than in vials, thereby allowing for more easy transport and storage. Dabi-like, edoxa-like, riva-like and apixa-like and heparin compounds are available. All inhibitor types are color-coded for recognition. These customized inhibitors can be manufactured on demand based on your laboratory needs.
Samples prepared using Inhibitor Ref can be used for checking the efficacy of DOAC-Stop™. This agent extracts DOACs from test samples relatively specifically. Thus, samples prepared with DOACs from Inhibitor Ref should show restoration of original test results after treatment with DOAC-Stop™. Samples prepared with Heparin Ref should not be modified by DOAC-Stop™.
1. Exner T, et al. Simple method for removing DOACs from plasma samples. Thrombosis Research. 2018; 16:1028-39.
2. Exner T, et. al. Effect of an activated charcoal product (DOAC-Stop™) intended for extracting DOACs on various other APTT-prolonging anticoagulants. Clin Chem Lab Med. 2019; 57: 690-696.
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